"We found that SARS-CoV-2 grew from pediatric samples less often than adult samples, and when the virus was successfully cultured, significantly less viable virus was present. These data, along with our local epidemiology, suggest that children do not appear to be the main drivers of SARS-CoV-2 transmission. Our findings have important public health and clinical implications. If younger children are less capable of transmitting infectious virus, daycare, in-person school and cautious extracurricular activities may be safe to continue, with appropriate precautions in place, and with lower risk to child care staff, educators and support staff than initially anticipated. Given the difficulties in keeping children isolated within the home environment and the significant impact of prolonged isolation on both child development and parental function (such as loss of work or income), a robust tool to decrease the length of, or need for, quarantine would be an important public health development."